Induction of protective immunity to malaria

Protective immunity to liver-stage malaria

Despite decades of research and recent clinical trials, an efficacious long-lasting preventative vaccine for malaria remains elusive. This parasite infects mammals via mosquito bites, progressing through several stages including the relatively short asymptomatic liver stage followed by the more persistent cyclic blood stage, the latter of which is responsible for all disease symptoms. As the li...

Chloroquine Inhibits Protective Immunity to Mouse Malaria

271 Received July 24, 2014; revised and accepted November 5, 2014. Published online December 4, 2014; doi: 10.1620/tjem.234.271. Correspondence: Yaming Cao, Department of Immunology, College of Basic Medical Sciences, China Medical University, No. 92 Beier Road, Heping District, Shenyang, Liaoning 110001, P.R. China. e-mail: [email protected] Early Treatment with Chloroquine Inhibits the Im...

Protective immunity to pre-erythrocytic stage malaria.

The development of a vaccine against malaria is a major research priority given the burden of disease, death and economic loss inflicted upon the tropical world by this parasite. Despite decades of effort, however, a vaccine remains elusive. The best candidate is a subunit vaccine termed RTS,S but this provides only partial protection against clinical disease. This review examines what is known...

Induction of Protective Antitumor Immunity

Induction of protective immunity to Listeria monocytogenes in neonates.

Neonates suffer unduly from infections and also respond suboptimally to most commonly used vaccines. However, a CD8 T cell response can be elicited in neonates if the Ag is introduced into the cytoplasm of APCs. Listeria monocytogenes (Lm) targets the cytoplasm of APC and is a strong CD8 and CD4 Th1-promoting vaccine vehicle in adult mice. We hypothesized that an attenuated strain of Lm would b...